Professor Ge Baoxue and Professor Mao Zhiyong from Tongji University discovered for the first time through a multi-year study that a synthetase called cGAS in the human body, once escaped from the cytoplasm into the nucleus, would “make evil” and inhibit DNA repair. Thereby promoting tumorigenesis. Experts pointed out that the research is of great significance for the development of new anti-tumor drugs. Related papers have recently been published online in the world's leading academic journal Nature, and have been featured in the internationally renowned academic journal Molecular Cell Biology Review.

It is reported that cGAS, as a synthetase, is a DNA recognition receptor, which can promote the production of interferon and immune factors with antiviral effects. During normal growth and metabolism, cells are affected by various internal and external factors. DNA is always damaged by different forms. DNA double-strand break is the most serious form of DNA damage. It cannot be repaired or repaired by mistake. Both will lead to an increase in genomic instability, which in turn induces chromosomal rearrangements and loss of genetic information, ultimately leading to apoptosis, aging, and even tumors. Professor Ge Baoxue and Professor Mao Zhiyong's research team found that when DNA damage occurs in cells, cGAS enzymes translocate into the nucleus and are “recruited” to the site of DNA damage, inhibiting DNA double-strand breaks through interference disruption. Damage repair, which in turn increases genomic instability and ultimately increases the risk of tumorigenesis. The team also found that cGAS enzymes inhibit DNA repair by a pathway that is completely independent of its DNA recognition function.

Gebao said that the synthetase in the human body has both good and evil. If it is in the cytoplasm, it usually does good things, can resist infection and activate the immune response; once it escapes from the cytoplasm, it will "make evil" when it enters the nucleus. Inhibits DNA repair of cells, thereby promoting tumorigenesis. cGAS is like a demon in a bottle. Whether it is "into nuclear" or not is the key. If the cGAS enzyme can be intervened and it is "closed" in the cytoplasm, it will not break into the "nucleus" to do bad things. This will become an important target in the development of anti-tumor drugs.

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