Chinese research team develops "Liquid Band-Aid"

Medical Network May 17th, May 15th, the British academic journal "Nature·Communication" published the research results of new bio-glue materials from Chinese research team, which can completely stop aortic injury and heart penetrating injury within seconds. Big bleeding. Dr. Hong Yi, a postdoctoral fellow at Zhejiang University School of Basic Medicine, who participated in the study, said that this kind of bio-glue can stop bleeding and body trapping in various operations, and it is expected to reduce the mortality and blood product consumption caused by uncontrollable bleeding. In the next step, the team plans to convert it into a medical device for clinical use, which may be available in about three to five years. In the process, the safety of the material is completely ensured or it takes a long time.
   "Magic glue" quick-acting hemostasis
On May 15th, Beijing time, the journal “Nature·Communication”, a subsidiary of the British academic journal Nature, published the research results of new bio-glue materials from Chinese research teams. The article describes the new bio-gel material, which can completely stop the aortic injury and the bleeding of the heart penetrating injury within a few seconds, and is safe and degradable without adverse reactions . The effect has been confirmed in pigs and is expected to be applied to the clinic in the future. .
It is understood that this paper entitled "A powerful hemostatic hydrogel that can repair arterial and cardiac hemorrhage" was completed by a team of Professor Ouyang Hongwei from Zhejiang University Medical College and Professor Zhu Linyong from East China University of Science and Technology. On the afternoon of May 16, Beiqing Daily reporter contacted one of the co-first authors of the paper, one of the postgraduate students of Zhejiang University School of Basic Medicine.
According to Hong Yi, this new material is a gel that mimics the connective tissue of the organism and can cure rapidly under ultraviolet light. This bio-gel ratio is close to the ratio of collagen to glycosaminoglycan in human connective tissue, and can be cured within 1 second after ultraviolet light irradiation.
"In short, it is a liquid band-aid that can be used in the body, mainly for various body plugging, such as various gastrointestinal bleeding and hemostasis during surgery." Hong Yi said.
Research results are expected to reduce bleeding mortality
In the video of the operation operation provided by the researchers, the reporter of Beiqing Daily saw that the researchers had injected a series of operations such as bio-glue and ultraviolet irradiation on a blood-sucking pig heart, and the bleeding disappeared within 10 seconds. No need to stitch again. Hong Yi said that for the wound of blood stasis, it is generally necessary to apply 1 or 2 times of glue, and it can stop bleeding in about 10 seconds. For the jet type bleeding wound, it needs to be applied 3 to 5 times, and it takes about 30 seconds to stop bleeding.
Hong Yi told the reporters of Beiqing Daily that in the experiment of pig heart, the pig was closed after the hemostasis of the heart. After two weeks, the pig's heart wound was sealed. “This shows that the bio-gel has good bio-meltability and can be degraded and absorbed. We have observed it for up to 8 months, and no side effects such as necrosis and large inflammation have been observed.”
“Fast hemostasis and wound closure are clinically important requirements. We also communicated with many surgeons in the study. They all said that the patient often died due to the inability to effectively control bleeding, and because it could not be quickly and effectively controlled. Bleeding causes huge consumption of blood products." Hong Yi said that the current clinical use of sutures for arterial and major organ bleeding is relatively slow and will cause new damage due to suture acupuncture, while new materials are on the one hand. It can stop bleeding quickly, and on the other hand, it does not produce new wounds.
It takes a long time to ensure material safety
Hong Yi said that he has applied for a number of Chinese patents and international patents for this bio-glue, and the next step is to convert it into a medical device for clinical use. “With our current schedule, it may be available in about 3 to 5 years, depending on the process of approval.”
Many netizens said that such a black technology means that the price will be very expensive. In this regard, Hong Yi said that the material of this bio-glue itself is not expensive, but the cost of R&D and approval will eventually be reflected in the price. “Our current estimate is that the price of bio-glue per tube will be lower than the current imported hemostatic products for clinical use.”
When talking about the difficulties faced by the current project, Hong Yi said that because this technology is a new technology, there is no standard in the process of product conversion, and it is difficult for the regulatory authorities to evaluate the safety of the product. point. “Our current research has already provided initial validation of in vivo efficacy and safety, but to be available to the market, further preclinical and clinical studies are needed to study the metabolic pathways of materials in the body to ensure safe future. Used in the human body."
At the same time, Hong Yi also mentioned that the mechanical properties of bio-glue can not completely replace suture in tissue suture. "For example, a knife wound that needs to be stitched together is not applicable, but the current version has been able to meet the hemostasis and wound closure requirements of internal organs." (Text / reporter Li Tao Li Zhuoya coordinator / Jiang Wei picture from the network )

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